We – EPG Team the bigge EPT gearbox & motors , vee pulleys, timing pulleys, couplings and gears manufacturing unit in China with 5 diverse branches. For far more details: Mobile/whatsapp/telegram/Kakao us at: 0086~13083988828 13858117778 0571 88828
Manufacturers EPT Top Good quality Large EPT Pharmaceutical Intermediate Powder 25-Hydroxycholesterol CAS NO.2140-forty six-seven
25-hydroxy Cholesterol is a aspect-chain substituted oxysterol derived from nutritional cholesterol that inhibits the cleavage of sterol regulatory element binding proteins (SREBPs) to suppress endogenous cholesterol synthesis in different mobile kinds. It has been implicated in a assortment of metabolic activities which includes cholesterol homeostasis and atherosclerosis as properly as antitumor activities as it has been revealed to induce apoptosis by way of down-regulation of Bcl-2 expression and activation of caspases. Immunomodulating capabilities have also been observed as the oxysterol can act as a LXR-R EPT ligand coupling cholesterol synthesis to T mobile proliferation, can decrease (EC50 ~ sixty five nM) IgA creation by B cel EPT in response to IL-2, and can suppress differentiation of monocytes into macrophages.
| Merchandise | Standard | Te EPT Benefits | |
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Identification |
A.H-NMR:Comply with the composition |
Complies |
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B.LC-MS:Comply with the composition |
Complies |
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C.The IR spectrum of sample need to be similar with that of reference standard |
Complies |
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D.HPLC-ESI-MS The retention time of the key peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Common planning, as acquired in the Assay. |
Complies |
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Crystallinity |
satisfies the demands. |
Complies |
|
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Reduction on drying |
≤2.% |
.19% |
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Heavy metals |
≤10 ppm |
<10ppm |
|
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H2o |
≤1.% |
.1% |
|
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Sulphated ash |
≤0.5%, identified on 1. g. |
.009% |
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Related substances |
Unspecified impurities: for each impurity |
≤0.ten% |
<0.10% |
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Whole Impurity |
≤0.5% |
.eighteen% |
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Purity |
≥99.% |
99.7% |
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Assay |
ninety nine.%~101.% (anhydrous material). |
99.8% |
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Microbiological Investigation |
|||
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Overall plate rely |
≤1000cfu/g |
Complies |
|
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Yea EPT and Moulds |
≤100cfu/g |
Complies |
|
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E. Coli. |
Absent |
Unfavorable |
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Salmonella |
Absent |
Unfavorable |
|
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S.aureus |
Absent |
Adverse |
|
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Storage |
Maintain in well-closed, gentle-resistant and airtight containers. |
Complies |
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We – EPG Team the bigge EPT gearbox & motors , vee pulleys, timing pulleys, couplings and gears manufacturing facility in China with 5 different branches. For much more details: Cellular/whatsapp/telegram/Kakao us at: 0086~13083988828 13858117778 0571 88828 The use of authentic equipment manufacturer’s (OEM) element quantities or logos , e.g. CASE® and John Deere® are for reference functions only and for indicating merchandise use and compatibility. Our business and the outlined alternative components contained herein are not sponsored, approved, or manufactured by the OEM.
